Key takeaway
The EPA has designated acetaldehyde, acrylonitrile, benzenamine, vinyl chloride, and MBOCA as High-Priority Substances for risk evaluation under TSCA. Simultaneously, it initiated a 12-month prioritisation process for benzene, ethylbenzene, naphthalene, styrene, and 4-tert-octylphenol, aiming to assess and mitigate risks associated with these chemicals.
A High-Priority designation means the EPA has identified a chemical as potentially posing unreasonable risks to health or the environment and will conduct a detailed risk evaluation to determine necessary regulatory actions.
The EPA provides a 90-day public comment period during the prioritisation phase, allowing stakeholders to submit information on chemical uses, hazards, and exposure risks. These inputs inform the agency’s final designations.
Source basis: https://www.epa.gov/assessing-and-managing-chemicals-under-tsca/prioritization-actions-under-tsca
On 18 December 2024, the U.S. Environmental Protection Agency (EPA) finalised the designation of five chemicals as High-Priority Substances under the Toxic Substances Control Act (TSCA) and began the yearlong prioritisation process for five additional chemicals. These actions underscore the EPA's commitment to identifying and addressing chemical risks to protect human health and the environment.
The EPA designated five chemicals—acetaldehyde, acrylonitrile, benzenamine, vinyl chloride, and 4,4’-methylene bis(2-chloroaniline) (MBOCA)—as High-Priority Substances for risk evaluation. This marks the conclusion of a 9–12 month prioritisation process.
Acetaldehyde (CASRN 75-07-0): Used in adhesives and petrochemicals, it is a probable human carcinogen linked to respiratory system irritation.Acrylonitrile (CASRN 107-13-1): Found in plastics and paints, this chemical is a probable carcinogen associated with respiratory irritation.Benzenamine (CASRN 62-53-3): Used in dyes and resins, it poses risks such as reproductive and blood-related health effects and is a probable carcinogen.Vinyl Chloride (CASRN 75-01-4): Widely used in manufacturing polyvinyl chloride (PVC), vinyl chloride is a known human carcinogen and linked to liver toxicity.4,4’-Methylene bis(2-chloroaniline) (CASRN 101-14-4): Primarily used in plastics and resins, this probable carcinogen is associated with genetic damage and other adverse health effects.
The EPA will now evaluate whether these chemicals present an unreasonable risk to health or the environment under their conditions of use. Risk evaluations exclude cost considerations and focus solely on scientific assessments. If risks are identified, regulatory measures will follow.
In parallel, the EPA initiated the prioritisation process for five new chemicals: benzene, ethylbenzene, naphthalene, styrene, and 4-tert-octylphenol. This process will span 12 months, during which the EPA will gather data and accept public input to determine whether these chemicals warrant High-Priority designations in December 2025.
The EPA has concluded that 1,2-dichloroethane poses unreasonable risks to workers under 15 industrial use conditions, launching the TSCA risk management phase for PVC and chlorinated chemical supply chains.
EPA’s proposed TSCA reporting deadline extension to May 2027 covers 16 chemicals including benzene, BPA and vinyl chloride. The delay reduces short term compliance pressure but prolongs uncertainty as the agency considers revising the rule, requiring companies to stay prepared for updated obligations.
The EPA has delayed the PFAS reporting start date to 2027, giving industry more time to prepare for TSCA compliance. While easing short-term pressure, the rule maintains extensive reporting obligations, requiring companies to strengthen data systems and supply chain transparency ahead of enforcement.
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